Clinical Case Challenge on Diagnostics and AMR

Some medical schools have gaps in diagnostics and antimicrobial resistance (AMR) content. We propose a challenge to solicit diagnostic and AMR clinical cases through a global call for participation. Diagnostics are laboratory tests to aid clinical management and/or guide treatment decisions. The purpose of the challenge is to encourage medical students, trainees, physicians, and others to collect or write clinical cases that could be used in medical education and shared online. The challenge has two types of clinical cases: original cases written specifically for the contest and not published before; adapted cases that have been published elsewhere and tailored for medical education use.


Guidelines for submissions are described below. The final deadline for cases is May 1st, 2018. The International Diagnostics Centre at the London School of Hygiene and Tropical Medicine is the main organizer of this contest. Send us your clinical case!

Watch the video to get an overview of the contest:


Questions: Contact our challenge coordinator at


Further Instructions


Types of cases. The challenge has two types of cases – original cases and adapted cases. 1) Original cases. These will be written specifically for the contest and not published before. At the time of submission, individuals will submit a statement confirming that the case has not been published before.

2) Adapted cases. These will have been published elsewhere and tailored by the challenge participant for medical education use. All adapted cases must contain appropriate attribution (details below). Only one submission will be allowed for each clinical case, so all adapted cases will need to be reported to the challenge contest (for example, if Prokesch, Lancet ID, 16, e190-e195 is the original case, this can be adapted only once). Adapated cases will be available on a first come, first serve basis. Individuals interested in submitting an adapted case will first send an email to with the complete citation. Our team will check that this citation has not yet been adapted and then give a green light to adapt the citation. Individuals who suggest adapting cases that have already been identified will not be allowed.


Format for cases. Each entry should have sections on history, exam/studies, differential, diagnosis, and more information.  The total word limit is 2000 words. Cases must include at least one image and feature clinical diagnostic tests.  Examples of clinical cases can be found at eMicrobe:


Criteria for judging cases. Each eligible case will be independently reviewed by three judges. Judges will include infectious diseases fellows, junior physicians, and others with expertise in clinical medicine. Judging criteria will include the following: (1) focus on diagnostics and AMR (cases that deal only with AMR are not eligible); (2) relevance to medical teaching, especially for medical students; and (3) capacity to enhance appropriate antibiotic use.


Prizes. The challenge has prizes for individuals who submit the best entries and also for groups (e.g., medical schools or student clubs) who help solicit the largest number of entries. Individual prizes include the following:

(1) commendation from the steering committee for all individual finalists, defined as all submissions reaching scored 7/10 or better; 

(2) potential publication in a journal special issue and/or online at eMicrobes

(3) individualized feedback from judges to all individual finalists; 

(4) oral presentation at the International Diagnostics Centre in London, with support for airfare, hotel, and meals for those finalists whose clinical cases receive the largest number of online views. 

Group prizes include the following:  

(1) commendation from the steering committee for groups that solicit at least ten clinical cases from within their group; 

(2) oral presentation at International Diagnostics Centre in London, with support for airfare, hotel, and meals for leaders of groups that solicit the largest number of high-quality submissions.


Timeline. All final entries are due by May 1st. For adapted cases, individuals need to submit their citation to the contest organizers as early as possible. All entries will be evaluated by July 1st. A set of finalist clinical cases will be available for public viewing and voting in July. Notifications about final commendations and prizes will be before the end of August.


Submission Requirements:


Only submissions in English will be accepted.  All submitting authors must submit a cover letter ( template here ) and consent form stating:

a.     No confidential patient information is revealed.

b.     If the case includes an image of a physical finding, a signed consent form from the patient or legal guardian has been obtained and is on file.

c.     All contributors are acknowledged in the letter and case report, and have agreed to the transfer of copyright of the case and images for public use (CC BY creative commons attribution).

d.     The case includes the affiliations of all the contributing authors.

e.     The units and reference ranges for all laboratory tests are specified.

f.      The case has not been published elsewhere (only for original cases).

g.     Appropriate attribution for adapted cases. This includes the original complete citation in addition to one of the following: (1) open access confirmation, denoting that the published version can be modified; OR (2) permission from the author that the original case can be modified.



(click to submit your case) 



1.     What is a case challenge?

A case challenge is an open contest to solicit clinical cases. Open contests have been widely by governments, private foundations, and others to spur creativity. More details about open contests for health are available here.

2.     What is an example of a strong clinical case?

Given that the purpose of the call for entries is to encourage creativity, we avoid giving specific examples. At the same time, published clinical cases would be useful for considering an appropriate level of detail. One difference between most published cases is that many focus on fascinating anomalies and we hope to have cases revealing common and clinically important AMR/diagnostics issues. Examples of general infectious diseases clinical cases can be found at eMicrobe:

3.     Does submitting a case study to this challenge preclude submission the same material to a medical conference or journal?

No, submitting to the challenge does not preclude a related submission. Regarding conferences, the case could be presented at a conference and also submitted to the challenge.  Regarding journals, submissions would need to be submitted to a journal that has an open access option (gold open access or green open access).

4.     How can I encourage my colleagues to join?

There are several ways to encourage your colleagues to join, including in-person events and social media. In-person events to promote participation in challenge contests include didactic sessions (student-focused presentations for medical students or other health students), feedback sessions (providing feedback to potential participants), and community-driven events. Social media strategies to encourage participation include banner announcements, email listservs, social network postings, and short text messages. More details can be found in our crowdsourcing challenges for health toolkit (click here).

5.     Do I need to be a qualified medical doctor to participate?

No, you do not need to be a qualified medical doctor to participate. However, we recommend that all participants have at least one qualified medical doctor review the clinical case submission prior to submission.

6.     What if more than one group wants to write up the same clinical case?

Each unique clinical case can only be submitted once. For the original category, only one submission can result from a clinical case. If we identify two submissions from a single case, the two groups will be asked to adjudicate. If they cannot identify a single contributor, both cases will be ineligible. For the adapted category, original citations must be sent to the challenge contest organizers  (via email to prior to adapting the case. The organizers will confirm that no one else has already adapted this clinical case.

7.     Are cases that have AMR and include some diagnostic test eligible? 

This challenge is focused on increasing training related to both diagnostics and AMR. Diagnostics are laboratory to aid clinical management and/or guide treatment decisions. All cases must have both elements in order to be eligible. We are most interested in clinical diagnostics available today in practice and how they can be most effectively used.

8.     For adapted cases, how do I ensure that there is appropriate attribution?

Adapted cases need to state that they have been adapted from a published case and include the citation for the original citation. In addition, they require one of the following: (1) open access confirmation, denoting that the published version can be modified; OR (2) permission from the author that the original case can be modified.

9.     Who is supporting this contest?

This contest is organized by the London School of Hygiene and Tropical Medicine’s International Diagnostics Centre. The contest is supported by an unrestricted grant from BioMérieux. The contest is advised by a Steering Committee who includes the following individuals: Rosanna Peeling (LSHTM), David van Duin (UNC), Xudong Zhou (Zhejiang University), Till Bachmann (University of Edinburgh), Daniel Berman (Nesta), Jason Ong (Monash), Claude Mabilat (BioMérieux), Joseph Tucker (LSHTM/UNC), Herman Goossens (University of Antwerp), Barbara Murray (University of Texas), Angela Caliendo (Brown), Robert Bonomo (Case Western), Robin Patel (Mayo), Patricia Garcia (Universidad Peruana Cayetano Heredia), Brian Kendall (Providence Portland Medical Center), Philip Onyebujoh (Africa CDC/WHO), Fiona Carragher (NHS), Brian Schwartz (UCSF), Vance Fowler (Duke), and Raj Gandhi (Harvard).


Diagnostics and AMR Resources 


1.     International Diagnostics Centre:

2.     BioMérieux and diagnostics:

3.     WHO and AMR:

4.     US CDC and AMR:

5.     BioMérieux Interactive: 

Role of the sponsor:

BioMérieux is the sole sponsor of the challenge, with an unrestricted educational grant to the London School of Hygiene and Tropical Medicine. BioMérieux has no role in the challenge design, implementation, or evaluation. All materials collected as part of the challenge will be evaluated by an expert panel and selected cases will be downloadable as medical education materials through an open access database.

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